Oncogenes Induce and Activate Endogenous p73 Protein
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چکیده
منابع مشابه
Oncogenes induce a reversal of replication’s fortunes
Oncogenes induce a reversal of replication’s for tunes N eelsen et al. describe how certain oncogenes can perturb DNA replication and induce DNA damage. Several oncogenes, including Cyclin E and Cdc25A, push cells precipitously into S phase, resulting in numerous DNA double-strand breaks (DSBs). But how S phase deregulation disrupts replication and induces DNA damage is unclear. To fi nd out, N...
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Despite the utility of recombinant adenoviral vectors in basic research, their therapeutic promise remains unfulfilled. Most engineered adenoviral vectors use a heterologous promoter to transcribe a foreign gene. We show that adenoviruses containing the cytomegalovirus immediate-early promoter induce the expression of the proapoptotic cellular protein TAp73 via the cyclin-dependent kinase-retin...
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Increased activation of specific protein kinase C (PKC) isoforms and increased nonenzymatic glycation of intracellular and extracellular proteins [the accumulation of advanced glycation end products (AGEs)] are major mechanistic pathways implicated in the pathogenesis of diabetic complications. Blocking PKC-beta(II) has been shown to decrease albuminuria in animal models of diabetes. To demonst...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m005737200